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TUMOR MARKER

برای مشاهده جدول تومور مارکرها کلیک نمائید.

 

تومور مارکر ها
USES
TUMOR MARKER ASSOCIATED CANCER(S) USUAL SAMPLE SCREEN HELP DIAGNOSE STAGE DETERMINE PROGNOSIS GUIDE CHOICE OF TREATMENT MONITOR SUCCESS OF TREATMENT & DETECT RECURRENCE COMMENTS
 AFP (Alpha-feto protein)  Certain cancers of the liverovariesand testes  Blood    X        X  Also elevated during pregnancyand acute and chronic hepatitis
 B2M (Beta-2 microglobulin) Multiple myeloma,chronic lymphocytic leukemia (CLL), and somelymphomas  Blood, urine,CSF        X    X Elevated in other conditions, such as kidney disease
 BCR-ABL Chronic myleloid leukemia (CML)and BCR-ABL-positive acute lymphocytic leukemia (ALL)  Blood, bone marrow    X       X  
 CA 15-3 (Cancer antigen 15-3)  Breast  Blood           X  Also elevated in other cancers, including lung,ovarian as well asbenign breast conditions, endometriosis,hepatitis; CA 15-3 or CA 27.29 are two differentassays for same marker
 CA 19-9 (Cancer antigen 19-9) Pancreatic, sometimes bile ducts, gallbladder, stomach, colon  Blood           X Also elevated in other forms of digestive tract cancer and non-cancer, thyroid disease,pancreatitis, bile duct obstruction, and inflammatory bowel disease
 CA-125 (Cancer antigen 125) Ovarian  Blood   X       X Also elevated with other cancers such as endometrial, peritoneal, fallopian tube, and non-cancers such as endometriosis,PID, some otherbenign diseases and conditions such as uterine fibroids,pregnancy
 CA-242 ( Cancer Antigen 242) Gastrointestinal cancer  Blood             To diagnosis and management of patients with known or suspected gastrointestinal carcinoma
 CA 27.29
Cancer Antigen 27.29 or Carbohydrate Antigen 27.29
Breast** (best used to detect recurrence or metastasis).
Colon, gastric, liver, lung, pancreatic, ovarian, prostate cancers
              Ovarian cysts, liver and kidney disorders, non-cancerous (benign) breast problems
 Calcitonin  Medullary thyroid carcinoma (MTC) and C-cell hyperplasia Blood    X       X Also elevated with other cancers, such as lung cancers andleukemias, but not used to detect these
 CEA (Carcino-embryonic antigen) Colorectal as well as pancreaticlung,breastovarian, medullary thyroid or other cancers  Blood      X X   X Elevated in conditions such asRAhepatitis, COPD, colitis,pancreatitis, and in cigarette smokers
 Chromogranin A(CgA) Neuroendocrinetumors (carcinoid tumors, neuroblastoma)  Blood    X        X May be most sensitive tumor marker for carcinoid tumors
 Fibrin/Fibrinogen Bladder  Urine            X  
 F-PSA 
(Free  Human Prostate Specific Antigen)
Prostate Cancer Blood             improve specificity of prostate cancer screening
 Gastrin G-cell hyperplasia, gastrin-producing tumor (gastrinoma)  Blood   X       X Also used to help diagnoseZollinger-Ellison syndrome
 hCG (Human chorionic gonadotropin, also called Beta-hCG) Testicular and trophoblastic disease, germ celltumors, choriocarcinoma  Blood, urine   X        X Elevated inpregnancy
 HE4 (Human epididymis protein 4) Ovarian Cancer  Blood             Usefull for monitoring recurrence or progressive diseas.in patient with epithelial ovarian cancer
 HPV(human papillomavirus) cervical cancer Cervical cells & genital warts            
 

Vulvar cancer

Vaginal cancer

Penile cancer

Anal cancer

Oropharyngeal cancers (cancers of the back of the throat, including the base of the tongue and tonsils) also can be evaluated

 JAK2 mutation Certain types of leukemia Blood, bone marrow   X         Also used to diagnose bone marrow disorderscharacterized by overproduction of one or more types of blood cells known asmyeloproliferative neoplasms (MPNs), especially polycythemia vera (PV)
 KRAS mutation Colorectalnon-small cell lung cancer Tissue        X  X   Helps determine whether treatment with targeted therapy is appropriate
 LDH (Lactate dehydrogenase) Testicular and othergerm cell tumors  Blood      X  X    X LDH is elevated in a wide variety of conditions and is often used to help identify the cause and location of tissue damage in the body and to monitor its progress; may be used in other cancers, such aslymphoma, melanoma, neuroblastoma.
M2PK 
 
(M2-Pyrovat Kinase

Colorectal (bowel)

cancer

stool             bleeding or non-bleeding bowel cancers, as well as polyps

 Monoclonal immunoglobulins

Bence-Jones Proteins 

Multiple myelomaand Waldenstroms macroglobulinemia Blood, urine 
 
urine
   X       X Cloned plasma cell with overproduction of one type of immunoglobulin, usually detected by protein electrophoresis orserum free light chains
 NMP 22 
(urine
test)
Bladder cancer               BPH (benign prostatic hypertrophy), prostatitis
NSE
(Neuron-specific Enolase)
Small cell lung cancer, neuroblastoma Blood or CSF            
That can elevate in
Proton pump inhibitor treatment, hemolytic anemia, hepatic failure, end stage renal failure, brain injury, seizure, stroke
 PAP 
Prostatic Acid Phosphatase
Metastatic prostate cancer**
Myeloma, lung cancer, osteogenic sarcoma
              Prostatitis, Gaucher\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\'s disease, osteoporosis, cirrhosis, hyperparathyroidism, prostatic hypertrophy
 Pro-Grp (Pro-gastrin-releasing peptide)
 
small cell lung carcinoma (SCLC)  Blood             For follow up of patients with small cell lung cancer
 PSA (Prostate specific antigen) Prostate  Blood X  X       X May be used to screen men at high risk due to family history; no consensus on use to screenasymptomaticmen; also elevated in benign prostatic hyperplasia (BPH), prostatitis, and with increasing age
 SCC (Squamous Cell Carcinoma(SCC)Antigen) Squamous cell carcinoma  Blood             Can be used as an aid to stage the carcinoma and determine the response to treatment
 S100
 
proteins
Malignantmelanoma Blood             Usefull for diagnosis
 Thyroglobulin  Thyroid  Blood,tissue           X Used after thyroid is removed to evaluate treatment
Urine Catecholamines:
VMA 
Vanillylmandelic Acid 
(24 hour collection of urine; it is a catecholamine metabolite)
Neuroblastoma Pheochromocytoma, ganglioneuroma, rhabdomyosarcoma, PNET               Dietary intake (bananas, vanilla, tea, coffee, ice cream, chocolate), medications (tetracyclines, methyldopa, MAOIs)

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